Rose Byrne

Rebecca Skloot

Renée Elise Goldsberry

Henrietta Lacks

Oprah Winfrey

Deborah Lacks

Ninja N. Devoe

Country Girl Mae

Lisa Arrindell

Aunt Ethel

Earl Poitier

Cousin Josh

L. Warren Young

Day Lacks

Patrick Walker

Cousin Fred

Jane Rumbaua

Mrs. Hsu

Sylvia Grace Crim

Mary Kubicek

Tian Richards

Lawrence (16 yrs.)

Kate Bond

Young Woman

Jazzy Ellis

Young Gladys

Jock McKissic

Carl the Mechanic

Kyanna Simone Simpson

Deborah (15-24YRS)

Tinashe Kajese

Sadie

Kayla Anderson

Johns Hopkins Student

Karen Wheeling Reynolds

Mrs. Gey

Todd Lee

Doctor

Jordan Eli Arellano

Young Sonny Lacks

Mary Shaw

Woman at Pump

Tatom Pender

Johns Hopkins Nurse

Christopher Robert Escobar

Chris the Intern

Clint Edwards

Scientist

De'Marco Arrington

Young Joe

Jaylon Gordon

Alfred

Tashaun Stanfill-Perry

Henrietta Lacks Neighbor

Matthew Bernard

Johns Hopkins Student

Sage Mayer

Young Boy

Elizabeth Hackler

Rebecca's Co-worker

David Shae

Reporter

Jaedon Godley

Davon Lacks

Tyvonna Jones

Elsie Lacks

Raphael Dante' Carr Jr.

Young Sonny

Miguel Angel Marrero

Scientist

Courtney B. Vance

Sir Lord Keenan Coefield

Reed Birney

Dr. George Gey

Alpha Trivette

First Administrator

Terrence V. Walker

Church Patron

Sean Freeland

Charlie

Reg E. Cathey

Zakariyyah

Gabriel Ebert

Christoph Lengauer

Kent Wagner

Scientist (uncredited)