(1996) Basquiat

as Mary Boone

(2006) Superman Returns

as Kitty Kowalski

(2004) Frankenstein

as Detective Carson O'Conner

(2000) Scream 3

as Jennifer Jolie

(1993) Flirt

as Emily

(2004) Laws of Attraction

as Serena

(1994) Mixed Nuts

as Rollerblader

(2002) The Sweetest Thing

as Judy Webb

(2007) Fay Grim

as Fay Grim

(2008) The Eye

as Helen Wells

(1998) You've Got Mail

as Patricia Eden

(2002) Personal Velocity

as Greta Herskowitz

(2001) The Anniversary Party

as Judy Adams

(1997) The House of Yes

as Jackie-O

(1993) Coneheads

as Stephanie

(2007) Broken English

as Nora Wilder

(2003) A Mighty Wind

as Sissy Knox

(1997) SubUrbia

as Erica

(1995) The Doom Generation

as Brandi

(1995) Kicking and Screaming

as Miami

(1996) Frisk

as Ferguson

(2003) The Event

as Nick Devivo

(2000) Best in Show

as Meg Swan

(1995) Party Girl

as Mary

(2006) The Oh in Ohio

as Priscilla Chase

(2004) Blade: Trinity

as Danica Talos

(2006) For Your Consideration

as Callie Webb

(1998) Henry Fool

as Fay Grim

(1996) Waiting for Guffman

as Libby Mae Brown

(2009) Happy Tears

as Jane

(2005) Adam & Steve

as Rhonda

(1995) Flirt

as Emily

(2009) Spring Breakdown

as Becky St. Germaine

(1997) The Daytrippers

as Jo Malone

(1994) Sleep with Me

as Athena

(2001) Josie and the Pussycats

as Fiona

(2011) Inside Out

as Claire Small

(2012) Price Check

as Susan Felders

(1997) Clockwatchers

as Margaret J. Burrell

(2012) Hemingway & Gellhorn

as Mary Welsh Hemingway

(2011) The Love Guide

as Angelica Lovecraft

(2025) The Parenting

as Brenda

(1997) Drunks

as Debbie

(2013) And Now a Word from Our Sponsor

as Karen Hillridge

(1994) Opera No. 1

as Fairy #1

(2013) Highland Park

as Shirley Paine

(2014) Grace of Monaco

as Madge Tivey-Faucon

(1997) Dinner at Fred's

as Celia

(2015) Irrational Man

as Rita

(1993) Dazed and Confused

as Darla

(2015) Ned Rifle

as Fay Grim

(1994) Dead Connection

as Denise

(2007) The Making of 'Fay Grim' or: How Do You Spell Espionage?

as Herself

(2016) Palacetor

as The Magician

(1998) The Misadventures of Margaret

as Margaret Nathan

(2024) Thelma

as Gail

(2018) The Con Is On

as Gina

(1994) Iris

as ---

(2016) Café Society

as Rad Taylor

(1993) Joey Breaker

as Irena Kildare

(2002) Hell on Heels: The Battle of Mary Kay

as Jinger Heath

(2016) Mascots

as Cindi Babineaux

(2004) The Sisters of Mercy

as ---

(1994) Amateur

as Girl Squatter

(2014) 21 Years: Richard Linklater

as Self - Actress

(2013) Hairbrained

as Sheila Pettifog

(1998) What Rats Won't Do

as Mirella Burton

(2023) Finally Home: Making Beau is Afraid

as Self

(2016) The Architect

as Drew

(2005) Making Dazed

as Self

(2017) Columbus

as Eleanor

(1998) Independent's Day

as Self

(1999) The Venice Project

as Myra

(2016) My Art

as Angie

(2020) Elsewhere

as Marie

(1993) Description of a Struggle

as Wanda

(1991) First Love, Fatal Love

as ---

(2003) Whether You Like It or Not: The Story of Hedwig

as Self

(2011) Grab

as Narrator

(2020) The Booksellers

as Self (voice)

(2011) Still Screaming: The Ultimate Scary Movie Retrospective

as Self

(2005) Nightstalkers, Daywalkers, and Familiars: Inside the World of 'Blade: Trinity'

as Self

(2006) Requiem for Krypton: Making 'Superman Returns'

as Self

(1993) Tracey Ullman Takes on New York

as ---

(2023) Beau Is Afraid

as Elaine Bray

Wild Horse Nine

as ---

(2008) The Return of Jezebel James

as Sarah Tompkins

(1989) The Simpsons

as Becky (voice)

(2003) The Ellen DeGeneres Show

as Self

(1999) Futurama

as Umbriel

(1988) LIVE with Kelly and Mark

as ---

(1997) The View

as Self

(1992) The Tonight Show with Jay Leno

as ---

(1979) CBS News Sunday Morning

as Self

(1998) Will & Grace

as Dorleen

(2004) Boston Legal

as Marlene Stanger

(2009) Parks and Recreation

as Lindsay Carlisle Shay

(2022) The Staircase

as Freda Black

(2016) Search Party

as Brick

(2009) Bored to Death

as ---

(2010) Louie

as Liz

(2020) High Fidelity

as Noreen Parker

(2011) New Girl

as Casey

(2013) Drunk History

as Mary Phelps Jacob

(2001) Further Tales of the City

as Connie Bradshaw Fetzner

(2004) Project Runway

as Self - Guest Judge

(2011) Portlandia

as Branding Expert

(2018) Lost in Space

as June Harris / Dr. Zoe Smith

(2014) The Tonight Show Starring Jimmy Fallon

as Self

(2022) Tales of the Walking Dead

as Blair Crawford

(2024) Mr. & Mrs. Smith

as Other Jane

(2023) Marvel's Moon Girl and Devil Dinosaur

as Kat Swan (voice)

(1998) More Tales of the City

as Connie Bradshaw

(1993) Tales of the City

as Connie Bradshaw

(2009) The Good Wife

as Vanessa Gold

(2021) The White Lotus

as Victoria Ratliff