(2005) The Interpreter

as Dot Woods

(2005) Capote

as Harper Lee

(1999) Being John Malkovich

as Maxine Lund

(1998) Out of Sight

as Adele Delisi

(2008) Synecdoche, New York

as Adele Lack

(2007) Into the Wild

as Jan Burres

(1996) Box of Moonlight

as Floatie Dupre

(2005) The 40 Year Old Virgin

as Trish Piedmont

(1999) 8MM

as Amy Welles

(2006) Friends with Money

as Christine

(1995) Living in Oblivion

as Nicole Springer

(2009) Genova

as Barbara

(2002) Death to Smoochy

as Nora Wells

(2010) Percy Jackson & the Olympians: The Lightning Thief

as Sally Jackson

(2002) S1m0ne

as Elaine Christian

(2008) Hamlet 2

as Brie Marschz

(2007) An American Crime

as Gertrude Baniszewski

(1992) The Gun in Betty Lou's Handbag

as Suzanne

(2010) Please Give

as Kate

(1996) If These Walls Could Talk

as Becky

(1998) The Real Blonde

as Mary

(2002) Full Frontal

as Lee

(1991) Johnny Suede

as Yvonne

(2010) Trust

as Lynn Cameron

(2009) Where the Wild Things Are

as Mom

(2010) Cyrus

as Jamie

(2005) The Ballad of Jack and Rose

as Kathleen

(2009) The Soloist

as Mary Weston

(2013) The Croods

as Ugga (voice)

(1996) Walking and Talking

as Amelia

(2022) Polar Bear

as Narrator (voice)

(2002) Lovely & Amazing

as Michelle Marks

(1999) Simpatico

as Cecilia

(1988) Survival Quest

as Cheryl

(2011) The Oranges

as Paige Walling

(2011) Peace, Love & Misunderstanding

as Diane Hudson

(2012) A Late Quartet

as Juliette Gelbart

(2013) Captain Phillips

as Andrea Phillips

(2012) Maladies

as Catherine

(2006) Making Capote: Concept to Script

as Self

(2013) Discord and Harmony: Creating a Late Quartet

as Self

(2013) Jackass Presents: Bad Grandpa

as Ellie Zisman

(2013) Enough Said

as Marianne

(2013) Begin Again

as Miriam Hart

(2018) Meet the Pickles - Behind the Scenes of Kidding

as Self

(2014) War Story

as Lee

(2024) Joker: Folie à Deux

as Maryanne Stewart

(2015) Elephant Song

as Nurse Susan Peterson

(2008) What Just Happened

as Lou Tarnow

(2015) Accidental Love

as Rep. Pam Hendrickson

(2017) We Don't Belong Here

as Nancy Green

(2017) November Criminals

as Fiona

(1998) Your Friends & Neighbors

as Terri

(2014) Jackass Presents: Bad Grandpa .5

as Ellie / Self

(2009) Collaborators

as Herself

(2012) Lost Angels: Skid Row Is My Home

as Narrator

(1990) Catchfire

as Trucker's girl

(2002) Adaptation.

as Catherine Keener (uncredited)

(2016) Unless

as Reta

(2017) Get Out

as Missy Armitage

(1991) Switch

as Steve's Secretary (Beth)

(2018) Nostalgia

as Donna Beam

(2012) All Noncombatants Please Clear the Set

as Self

(2018) Sicario: Day of the Soldado

as Cynthia Foards

(1996) Boys

as Jilly

(2018) Incredibles 2

as Evelyn Deavor (voice)

(2018) Little Pink House

as Susette Kelo

(2020) The Croods: A New Age

as Ugga Crood (voice)

(1996) Heroine of Hell

as Magda

(1986) The Abduction of Allison Tate

as Linda Kellogg

(2009) Tell Them Anything You Want: A Portrait of Maurice Sendak

as Herself

(2021) No Future

as Claire

(2022) The Adam Project

as Maya Sorian

(1996) The Destiny of Marty Fine

as Lena

(1986) About Last Night...

as Cocktail Waitress

(2021) Dear Diary: World's First Pranks

as Ugga (voice)

(1993) The Cemetery Club

as Esther's Daughter (uncredited)

(2002) Death to Smoochy: Bloopers & Outtakes

as Self

(2002) Death to Smoochy: Behind the Scenes Documentary

as Self

(2003) The Ellen DeGeneres Show

as Self

(1986) L.A. Law

as Waitress (uncredited)

(1996) The Daily Show

as Self

(1992) The Tonight Show with Jay Leno

as ---

(1987) Ohara

as ---

(1953) The Oscars

as Self

(2021) Brand New Cherry Flavor

as Boro

(2018) Forever

as Kase

(1989) Seinfeld

as Nina West

(2015) Show Me a Hero

as Mary Dorman

(2018) Kidding

as Deirdre

(1996) The Rosie O'Donnell Show

as Self - Guest

(2019) Modern Love

as Julie