Meg Ryan

Annie Reed

Tom Hanks

Sam Baldwin

Ross Malinger

Jonah Baldwin

Bill Pullman

Walter

Rosie O'Donnell

Becky

Barbara Garrick

Victoria

Rob Reiner

Jay

Gaby Hoffmann

Jessica

Rita Wilson

Suzy

Victor Garber

Greg

Tom Riis Farrell

Rob

Carey Lowell

Maggie Baldwin

Le Clanché du Rand

Barbara Reed

Kevin O'Morrison

Cliff Reed

David Hyde Pierce

Dennis Reed

Valerie Wright

Betsy Reed

Frances Conroy

Irene Reed

Tom Tammi

Harold Reed

Calvin Trillin

Uncle Milton

Caroline Aaron

Dr. Marcia Fieldstone

Linda Wallem

Loretta

LaTanya Richardson Jackson

Harriet

Tom McGowan

Keith

Steve Mellor

Wyatt

Marguerite Schertle

Baltimore Waitress

Dana Ivey

Claire

Brian McConnachie

Bob

Matt Smith

Mailman

Amanda Maher

Clarise

Victor Morris

Seattle Maitre D'

Philip Mihalski

Seattle Waiter

Donald J. Lee Jr.

Seattle Detective

Mary A. Kelly

Nervous Woman on Airplane

Diane Sokolow

Tiffany Saleswoman

Hannah Cox

Jessica's Mother

Rich Hawkins

Jessica's Father

Tamara Plank

Stewardess

Michael Badalucco

New York Taxi Dispatcher

Jeff Mazzola

New York Taxi Dispatcher

Philip Levy

Taxi Driver

Julie Janney

Cynthia

Tony Zazula

Maitre D'

John Boylan

Elevator Man

Robert Livingston

Elevator Man

Butch Stevenson

Valet

Sidney Armus

Information Booth Man

Philip Anagnos

Car Driver (uncredited)

Jason Bortz

Baltimore Mail Clerk (uncredited)

Scott Duthie

Tourist (uncredited)

William Rossman

Driver (uncredited)

Nick Taylor

Bartender (uncredited)