David Kaufman

Danny Fenton / Danny Phantom (voice)

Martin Mull

Vlad Masters / Vlad Plasmius (voice)

Brian Cox

Pariah Dark (Voice)

Colleen O'Shaughnessey

Jazz Fenton (Voice)

Rickey D'Shon Collins

Tucker Fenton (Voice)

Grey DeLisle

Samantha "Sam" Manson (Voice)

Ron Perlman

Vice Principle Lancer (Voice)

S. Scott Bullock

Dash Baxter (Voice)

Maria Canals-Barrera

Paulina (Voice) (As Maria Canals)

Dee Bradley Baker

Mikey / Nathan / Lance Thunder (voice)

Michael Dorn

The Fright Knight (Voice)

Peter MacNicol

Sidney Poindexter (Voice)

Phil Morris

Damon Gray (Voice)

Laraine Newman

Pam (Voice)

Rob Paulsen

Jack Fenton / The Box Ghost / Nicolai Technus (voice)

Kevin Michael Richardson

Skulker (Voice)

James Sie

Kwan (Voice)

Kath Soucie

Maddie Fenton (Voice)

Tara Strong

Ember / Tiffany Snow (Voice)

Cree Summer

Valarie Gray (Voice)