Gwyneth Paltrow

Donna Jensen

Christina Applegate

Christine Montgomery

Mark Ruffalo

Ted Stewart

Candice Bergen

Sally Weston

Joshua Malina

Randy Jones

Mike Myers

John Witney

Kelly Preston

Sherry

Stacey Dash

Angela Samona

Rob Lowe

Co-Pilot Steve Bench

Marc Blucas

Tommy Boulay

Frederick Coffin

Mr. Stewart

Jon Polito

Roy Roby

Concetta Tomei

Mrs. Stewart

Robyn Peterson

Donna's Mom

Nadia Dajani

Paige

John Francis Daley

Rodney

Priscilla Inga Taylor

Janette

Matt Roth

Greg

DonnaMarie Recco

Tammy

Daniel Raymont

British Man

Connie Sawyer

Grandma Stewart

David Hayward

Pete

Chelsey Cole

Donna - 6 Years Old

Troy Evans

Customer

Merrilee McCommas

June

George Kennedy

Passenger Requesting Vodka (uncredited)

Candice T. Cain

CDG Passenger (uncredited)

Valentin Siroon

Flight Attendant Trainee (uncredited)

Jessica Capshaw

Royalty International Flight Attendant (uncredited)

Mary McNeal

Ted's Study Partner Mary

Stephanie Miller

TV Interviewer

Susan Mosher

Senior Flight Attendant

Victoria Garcia-Kelleher

Clerk #1 (uncredited)

Stephen Tobolowsky

Frank Thomas (uncredited)

Anastacia Spiegel

Runway Model at Airport (uncredited)

Amanda Wycoff

Flight Attendant Trainee (uncredited)

Dawn-Marie Whelan

Flight Attendant Trainee Anne (uncredited)

Jeff Yagher

Ghost Rider

Greg Bronson

Fashion Photographer (uncredited)

Roark Critchlow

Tennis Pro (uncredited)

Chad Everett

Jack Weston (uncredited)

Wayne Federman

Whiskey Sour Man (uncredited)

Clarinda Ross

Diaper Woman (uncredited)

Jackie Zane

Passenger in Terminal (uncredited)