Jeffrey Wright

Thelonious 'Monk' Ellison

John Ortiz

Arthur

Erika Alexander

Coraline

Leslie Uggams

Agnes Ellison

Sterling K. Brown

Clifford Ellison

Skyler Wright

Brittany

John Ales

Leo

Patrick Fischler

Mandel

Carmen Cusack

Gilda

Joseph Marrella

Matthew Wilson

Stephen Burrell

Jordan Phillips

Issa Rae

Sintara Golden

Nicole Kempskie

Sintara's Moderator

Becki Dennis

Clinic Receptionist

Tracee Ellis Ross

Lisa Ellison

Myra Lucretia Taylor

Lorraine

Ryan Richard Doyle

Ned

Kate Avallone

Woman on Patio

Dustin Tucker

Phillip

Michael Jibrin

Jelani

Michele Proude

Bulger's Nurse

David De Beck

Dr. Bulger

Okieriete Onaodowan

Van Go Jenkins

Keith David

Willy the Wonker

Miriam Shor

Paula Baderman

Raymond Anthony Thomas

Maynard

Greta Quispe

Luz Borquez

J.C. MacKenzie

Carl Brunt

Elle Sciore

Layne

Adam Brody

Wiley Valdespino

Justin Andrew Phillips

Arthur's Intern

Neal Lerner

Wilson Harnet

Jenn Harris

Ailene Hoover

Bates Wilder

Jon Daniel Sigmarsen

Jason Armani Martinez

Nursing Home Orderly

Michael Cyril Creighton

John Bosco

Celeste Oliva

Dr. Tiefel

Megan Robinson

Kenya Dunston

Christopher Barrow

Burt

Alexander Pobutsky

Kenny

Tokunbo Joshua Olumide

Alvin

Chhoyang Cheshatsang

Wiley's Assistant

Michael Malvesti

Plainclothes Cop

Samantha Gordon

Gaby (uncredited)