Will Smith

Oscar (voice)

Robert De Niro

Don Lino (voice)

Renée Zellweger

Angie (voice)

Jack Black

Lenny (voice)

Angelina Jolie

Lola (voice)

Ziggy Marley

Ernie (voice)

Martin Scorsese

Sykes (voice)

David P. Smith

Crazy Joe (voice)

Doug E. Doug

Bernie (voice)

Michael Imperioli

Frankie (voice)

Vincent Pastore

Luca (voice)

Peter Falk

Don Feinberg (voice)

Katie Couric

Katie Current (voice)

Phil LaMarr

Prawn Shop Owner (voice)

Shelley Morrison

Mrs. Sanchez (voice)

David Soren

Shrimp / Worm / Starfish #1 / Killer Whale #2 (voice)

Bobb'e J. Thompson

Shortie #1 (voice)

Kamali Minter

Shortie #2 (voice)

Emily Lyon Segan

Shortie #3 (voice)

Lenny Venito

Giuseppe / Great White #1 (voice)

Saverio Guerra

Pontrelli (voice)

Mark Swift

Announcer (voice)

James Madio

Great White #2 / Hammerhead (voice)

Frank Vincent

Great White #3 (voice)

Joseph Siravo

Great White #5 (voice)

Steve Alterman

Messenger Fish / Tip Fish #2 (voice)

Jenifer Lewis

Motown Turtle (voice)

Sean Bishop

Tip Fish #1 / Great White #4 / Whale / Killer Whale #1 (voice)

James Ryan

Cashier / Oyster / Clown Whale (voice)

Latifa Ouaou

Whale Wash Co-Worker (voice)

David Yanover

Taxi Fish (voice)

Christina Aguilera

Christina (voice) (uncredited)

Missy Elliott

Missy (voice) (uncredited)